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Designed to backup permissions to typical directories that have unique permissions, then use icacls to reset permissions on C:, then restore the permissions on these special directories. This is currently a beta script, no errors are reported in Powershell ISE - Script Analyzer. Does need testing and refinement for professional usage.

icaclsresetandbackuptest.ps1

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+# Define the system folders to back up
+$SystemFolders = @( "Users", "Program Files", "Program Files (x86)", "ProgramData", "Windows"
+)
+
+# Loop through each system folder
+foreach ($Folder in $SystemFolders) { # Check if the folder exists
+    if (Test-Path -Path $Folder) {
+        # Save the permissions of the folder to an ACL file
+        & icacls $Folder /save "$Folder.acl" /t } }
+
+# Define the special folders to back up
+$SpecialFolders =@( "WindowsApps", "Program Files\\WindowsApps", "Program Files\\ModifiableWindowsApps", "Windows\\SystemApps", "Windows\\SysWOW64\\config\\systemprofile\\AppData\\Local\\Microsoft\\WindowsApps"
+
+)
+
+# Loop through each special folder
+foreach ($Folder in $SpecialFolders) { # Check if the folder exists
+    if (Test-Path -Path $Folder) {
+        # Save the permissions of the folder to an ACL file
+        & icacls $Folder /save "$Folder.acl" /t } }
+
+# Reset the permissions on C:
+& icacls C:\\ /reset /t
+
+# Loop through each special folder again
+foreach ($Folder in $SpecialFolders) {
+    # Check if the ACL file exists
+    if (Test-Path -Path "$Folder.acl") {
+        # Restore the permissions of the folder from the ACL file
+        & icacls C:\\ /restore "$Folder.acl"
+    }
+}
+
+# Loop through each special folder again
+foreach ($Folder in $SpecialFolders) {
+    # Check if the ACL file exists
+    if (Test-Path -Path "$Folder.acl") {
+        # Restore the permissions of the folder from the ACL file
+        & icacls C:\\ /restore "$Folder.acl"
+    }
+}